棉纤维素 ≥98%(HPLC), 分析标准品
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| 包装规格: | 10mg in glass bottle |
| 产品描述: | 从 Hibiscus vitifolius 中分离得到的一种黄酮,具有抗氧化、抗炎、抗癌、抗衰老、抗糖尿病、镇痛和保护肝脏的活性。Gossypin 抑制 NF-κB 和 NF-κB 的调节基因表达。在小鼠原代骨髓细胞和 RAW264.7 细胞中,Gossypin 也可抑制 RANKL 诱导的破骨细胞形成。Gossypin is a flavonoid glycoside originally isolated from H. vitifolius that has diverse biological activities. It inhibits RANKL-induced osteoclastogenesis in RAW 264.7 cells when used at a concentration of 5 µM. Gossypin inhibits Aurora B kinase (IC50 = 11.07 µM in a cell-free assay using the human enzyme), as well as Aurora A kinase and p90 ribosomal S6 kinase 2 (RSK2) at 20 µM. It induces cell cycle arrest at the G2/M phase and apoptosis in HGC-27 gastric cancer cells. Gossypin decreases lactate dehydrogenase (LDH) release induced by the glutathione-depleting agent D,L-buthionine (S,R)-sulfoximine in primary rat cortical cells (IC50 = 7.4 µg/ml). It reduces acetic acid-induced writhing in mice, an effect that can be reversed by the opioid antagonist naloxone, in a dose-dependent manner. |
| 保存条件: | -20°C |
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