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胆甾烯酮  99.6%(HPLC),分析标准品

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包装规格：20mg 100mg in glass bottle
溶解性：溶于DMSO(2mg/mL超声)
产品描述：胆固醇的中间氧化产物，主要在肝脏中代谢。Cholestenone 在膜中具有很高的流动性，会影响胆固醇的翻转和外排。Cholestenone 可能会导致细胞长期功能缺陷。 Cholestanone is a cholesterol metabolite that has a keto group in place of the 3-hydroxy group on cholesterol. It decreases TGF-β-induced Smad2 phosphorylation and TGF-β expression and prevents inhibition of DNA synthesis by TGF-β in Mv1Lu cells. Increased fecal excretion of cholestenone is correlated with an increased risk of colorectal cancer. Cholestenone reduces serum cholesterol levels in a variety of animal models but is toxic to rats due to induction of hypertrophy and reduction in the activity of the adrenal gland. It has been used as synthetic intermediate in the synthesis of steroids.
保存条件：室温

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