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Senecionine  ≥98%(HPLC),分析标准品

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包装规格：5mg in glass bottle
产品描述：基本信息 产品编号： S60017 产品名称： Senecionine CAS: 130-01-8   储存条件 粉末 -20℃ 四年 分子式： C18H35NO5 溶于液体 -80℃(避光) 6个月 分子量： 335.39 -20℃(避光) 1个月 化学名：  Senecionan-11,16-dione,12-hydroxy- Solubility (25°C)：   体外:   DMSO   Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 2.9816mL 14.9080mL 29.8160mL   生物活性 产品描述 一种从Senecio vulgaris中分离出来的吡咯里西啶生物碱。Senecionine对动物和人类有毒。 靶点 Others 体外研究 Pyrrolizidine alkaloids (PAs) are considered to be one of the most hepatotoxic groups of compounds of plant origin and are present in about 3% of the world's flowering plants.Most PAs represent a considerable health hazard to both livestock and humans through the consumption of plants and PA-contaminated products such as milk,honey,herbal teas,and medicines. 体内研究 Upon intravenous administration and oral administration of Senecionine and Adonifoline,significant differences in pharmacokinetics were observed,with the Senecionine and Adonifoline being absorbed fast with lower bioavailability and being quickly metabolized to PA N-oxides and hydroxylation products of PAs or their N-oxides.Senecionine fails to stimulate epoxide hydrase,it diminishs the activity of glutathione-s-transferase,aminopyrine demethylase and AHH.Twice-weekly injections of a third constituent,senecionine,beginning on Day 12 or later,results in premature deliveries in three of seven rats,and the pups from all litters are stillborn or die shortly after birth.   推荐实验方法(仅供参考) 动物实验:   Rats Swiss albino rats weighing 155-175g are incubated for 3 consecutive days with seneciphylline and senecionine at a daily dose of 40 or 80mg/kg body wt.Control animals received normal saline only.The animals are killed 24h after the last dose.The livers are removed, weighed and then homogenized in 1.15% KCI,0.02 HEPES (pH 7.4).
保存条件：-20°C

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