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诃子次酸  ≥98%(HPLC),分析标准品

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包装规格：5mg 10mg in glass bottle
产品简介：一种从 Terminalia chebula 中分离出的酚羧酸化合物，具有很强的抗氧化活性，它打破了由晚期糖基化终产物 (AGEs) 诱导的蛋白质交联，抑制了 (AGEs) 的形成。Chebulic acid 对控制代谢参数升高、氧化应激和肾损害有效，支持其在糖尿病肾病中的有益作用。 Chebulic acid is a phenol that has been found in T. chebular and has diverse biological activities. It reduces production of reactive oxygen species in human umbilical vein endothelial cells induced by glyceraldehyde-related advanced glycation end products when used at a concentration of 100 µg/ml. Chebulic acid reduces glycer-AGE-induced adhesion of HUVECs to THP-1 monocytes. It induces Nrf2 nuclear translocation and glutathione synthesis and inhibits glycer-AGE-induced collagen accumulation, a marker of fibrosis, in LX-2 hepatic stellate cells. In vivo, chebulic acid increases serum insulin levels and reduces blood urea nitrogen levels, proteinuria, albuminuria, and serum glucose levels in a diabetic rat model of ischemia-reperfusion-induced nephropathy.
溶解性：溶于DMSO（260mg/mL 超声）
保存条件：-20℃

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