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印楝素 B  ≥98%(HPLC),分析标准品

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包装规格：1mg 5mg in glass bottle
产品描述：基本信息 产品编号： A11124 产品名称： Azadirachtin B CAS: 106500-25-8   储存条件 粉末 -20℃ 四年     分子式： C33H42O14 溶于液体 -80℃ 两年 分子量 662.68     化学名：  3-tigloylazadirachtol   生物活性 产品描述 从 Azadirachta indica 种子仁中分离的柠檬苦素,增加碱性磷酸酶 (ALP) 活性并刺激成骨细胞分化。 靶点 Plutella xylostella Alkaline phosphatase (ALP) Epstein-Barr virus early antigen (EBV-EA) 体外研究 Azadirachtin B (1pM-100µM; 48 hours; Osteoblast cells) treatment shows highest proliferation at 10nM and 100pM concentrations in osteoblast cells. Azadirachtin B increases expression of RunX-2 -2.5 fold at 10nM concentration, ALP expression -2.8 fold at 10nM and 100pM concentration and OCN expression -2.5 folds at 10nM as compared with control. Azadirachtin B (Compound 4) exhibits toxicity to the diamondback moth (Plutella xylostella) with an LD50 of 4.85-1.06 µg/g body weight, in 92 h. Azadirachtin B (compound 21) exhibits moderate or potent inhibitory effects (IC50 value of 384 mol ratio/32pMol TPA) against the Epstein-Barr virus early antigen (EBV-EA) activation induced by tetradecanoylphorbol-13-acetate (TPA) Cell Proliferation Assay Cell Line: Osteoblast cells Concentration: 1pM, 100pM, 10nM, 1µM, 100µM Incubation Time: 48 hours Result: Showed highest proliferation at 10nM and 100pM concentrations in osteoblast cells. 体内研究 On evaluation of Azadirachtin B (compound 21; oral administration) for its anti-tumor-initiating activity on the two-stage carcinogenesis of mouse skin tumor induced by peroxynitrite (ONOO-; PN) as an initiator and TPA as a promoter, this exhibited marked inhibitory activity
保存条件：-20℃

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