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Jatrorrhizine hydroxide  ≥98%(HPLC),分析标准品

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包装规格：10mg in glass bottle
溶解性：溶于DMSO（3.33 mg/mL 超声)
产品描述：基本信息 产品编号： J10035 产品名称： Jatrorrhizine hydroxide CAS: 483-43-2   储存条件 粉末 2-8℃ 四年 分子式： C20H21NO5 溶于液体 -80℃(避光) 6个月 分子量： 355.38 -20℃(避光) 1个月 化学名：  Dibenzo[a,g]quinolizinium,5,6-dihydro-3-hydroxy-2,9,10-trimethoxy-,hydroxide Solubility (25°C)：   体外:   DMSO   Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 2.8139mL 14.0694mL 28.1389mL 5mM 0.5628mL 2.8139mL 5.6278mL 10mM 0.2814mL 1.4069mL 2.8139mL   生物活性 产品描述 是从黄连中分离得到的生物碱，具有神经保护、抗菌、抗疟原虫和抗氧化活性。 靶点 IC50:872nM (AChE) 体外研究 Jatrorrhizine has antiplasmodial and antiamoebic activity,it against Plasmodium falciparum and E.histolytica with IC50 values of 3.15 and 82.7µM,respectively.The hOCT2 (organic cation transporter 2),hOCT3,and PMAT (plasma membrane monoamine transporter) are capable of transporting monoamine neurotransmitters in the brain.Jatrorrhizine has the inhibitory potency of jatrorrhizine on 5-HT and NE uptake in hOCT2-,hOCT3-,and PMAT-transfected cells.Jatrorrhizine strongly inhibits PMAT-mediated MPP+uptake with an IC50 value of 1.05μM and reduces 5-HT and NE uptake mediated by hOCT2,hOCT3,and hPMAT with IC50 values of 0.1-1μM (for OCT2 and OCT3) and 1-10μM (for PMAT).Clearance of neurotransmitters released into the synaptic cleft is defined by two distinct processes. Uptake-1,the common target of current applied antidepressants,is comprised of the serotonin transporter (SERT),the “SERT”,had a high affinity but low capacity to take up [3H]5-HT.Uptake-2 transporters are an important supplementary regulation system in monoamine clearancethought to be the“NET”,has low affinity but high capacity to take up [3H]5-HT into brain slices.Jatrorrhizine significantly inhibited 5-HT and NE uptake in synaptosomes at 25μM and 50μM. 体内研究 Jatrorrhizine (intraperitoneal injection;5,10,20mg/kg) can significantly reduce the duration of immobility when compared with vehicle control group in tail suspension test (TST). Animal Model: Male ICR albino mice Dosage: 5,10,20mg/kg Administration: Intraperitoneal injection;5,10,20mg/kg Result: Reduced immobility period in tail suspension test.
保存条件：2-8℃

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