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联氟砜  分析标准品

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产品描述：基本信息 产品编号：F10121 产品名称：Fluensulfone CAS: 318290-98-1   储存条件 粉末 -20℃ 四年     分子式： C7H5ClF3NO2S2 溶于液体 -80℃ 两年 分子量 291.69 -20℃ 一个月 化学名：  5-chloro-2-(3,4,4-trifluorobut-3-en-1-ylsulfonyl)-1,3-thiazole   Solubility (25°C)   体外 DMSO 100mg/mL (342.82mM; Need ultrasonic) Ethanol   Water 0.73mg/mL (2.50mM; Need ultrasonic) 体内 现配现用   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 3.4282mL 17.1409mL 34.2818mL 5mM 0.6856mL 3.4282mL 6.8564mL 10mM 0.3428mL 1.7141mL 3.4282mL   生物活性 产品描述 一种新的化学防治植物寄生线虫的杀线虫剂。 靶点/IC50 Parasite   体外研究 Lower concentrations of Fluensulfone delay development: 100μM Fluensulfone causes a slight delay as at 66 h fewer worms have reached the adult stage whilst at 300μM no worms reach the adult stage at 66 h and some fail to reach L4. Adult hermaphrodites lay fewer eggs in the presence of 1mM Fluensulfone. Fluensulfone is also found to reduce the viability of eggs. After 3 h incubation with 100μM to 1mM Fluensulfone the thrashing rate is significantly inhibited, with maximal inhibition occurring with 1mM. After 1 h both 300μM and 1 mM Fluensulfone cause a significant and reversible inhibition of pharyngeal pumping relative to the vehicle control. Fluensulfone (500μM) inhibits the frequency of body bends in one day old adult hermaphrodites off food after 2 h exposure.   体内研究 In an in vivo investigation, female mice are treated with Fluensulfone (or isoniazid as a positive control) for 3 and 7 days.Quantification of the cell proliferation by manual counting of BrdU-positive and BrdU-negative cells in the bronchiolar epithelium reveals an approximately fourfold increase of cell proliferation upon treatment with Fluensulfone and the positive control isoniazid compare with control. Increased cell proliferation is observed at 3 days but have reverted to the control level at day 7 .   推荐实验方法(仅供参考) 细胞实验:   Cell Assay For these assays worms of different developmental stages are incubated in liquid with and without Fluensulfone for up to 24h, and paralysis is scored. 400μL of M9 phosphate buffer with either Fluensulfone (100μM, 200μM or 1mM) or vehicle (0.5% acetone) is put into each well of a 24 well plate (5 replicates for each Fluensulfone concentration). 5μL suspension of age synchronised C. elegans (L1, L2/3, L4 or one day old adult) is added to each well. Each well contains approximately 50 to100 worms. The number of worms not moving at 1, 2, 3, 4, 5, 6 and 24 h is determined. The experiment is conducted on two separate occasions with five replicates.   动物实验:   Animal Administration Groups of 10 female specific pathogen-free CD-1 mice each are treated with untreated diet, diet containing 1200mg/kg Fluensulfone (high dose in carcinogenicity study), or 1305mg/kg of isoniazid as a positive control substance for 3 or 7 days,respectively. Two and 14 h before sacrifice, the animals are injected ip with 100μL of a 10mg/mL aqueous bromodeoxyuridine (BrdU)-solution. Sacrifice by exsanguination under deep irreversible pentobarbital narcosis is performed early in the morning to assure that the animals are exposed to the test item until shortly before sacrifice.
保存条件：-20℃

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