生物试剂
>
生化试剂
>
分析化学
> 旋覆花内酯
加入收藏 取消收藏

旋覆花内酯  ≥98%(HPLC),分析标准品

促销价¥{{model.attbuying.price}}

市场价¥0.00

累计销量0 累计评价0 人评论

别称 {{model.alias}}
中文名称 {{model.name}}
英文名称 {{model.enname}}
品牌 {{model.brand}}
CAS {{model.cas}}
分子式
分子量 {{model.molecularweight}}
MDL {{model.mdl}}
货号 {{model.procode}}
数量

+ -

件 库存{{model.attbuying.number}}件
立即购买 加入购物车 下载说明书

看了又看
包装规格：5mg in glass bottle
产品描述：基本信息 产品编号： I10140 产品名称： Inulicin CAS: 33627-41-7   储存条件 粉末 2-8℃ 四年 分子式： C17H24O5 溶于液体 -80℃(避光) 6个月 分子量： 308.40 -20℃(避光) 1个月 化学名：  2H-Cyclohepta(b)furan-2-one,3,3a,4,5,8,8a-hexahydro-4-hydroxy-6-(3-hydroxypropyl)-5,7-dimethyl-3-methylene-,6-acetate,(+)- Solubility (25°C)：   体外:   DMSO   Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 3.2429mL 16.2143mL 32.4286mL 5mM 0.6486mL 3.2429mL 6.4857mL 10mM 0.3243mL 1.6214mL 3.2429mL   生物活性 产品描述 Inulicin(1-O-Acetylbritannilactone)是一种活性化合物，抑制VEGF介导的Src和FAK活化。 靶点 NF-κB COX-2 体外研究 Inulicin (1-O-Acetylbritannilactone) inhibits angiogenesis and lung cancer cell growth through regulating VEGF-Src-FAK signaling.Inulicin dose-dependently inhibits vascular endothelial growth factor (VEGF)-induced proliferation,migration,and capillary structure formation of cultured human umbilical vascular endothelial cells (HUVECs).Treatment of A549 NSCLC cells with Inulicin results in cell growth inhibition and Src-FAK in-activation.The potential effect of Inulicin is tested ton Src and FAK phosphorylation in A549 lung cancer cells.Significant high levels of Src and FAK phosphorylations are noticed a in A549 cells,which are both inhibited by treatment of Inulicin (5μM and 10μM).Src and FAK are both important for cancer cell proliferation.Thus,A549 cell growth,tested by MTT assay and clonogenicity assay,is remarkably inhibited by corresponding Inulicin treatment.The anti-A549 cell growth activity of Inulicin is again dose-dependent.Inulicin (1-OAcetylbritannilactone) isolated from Inula britannica-F.,inhibits inflammatory responses in vascular smooth muscle cells (VSMCs).Inulicin (5,10,20μM) has several concentration dependent effects,including inhibition of lipopolysaccharide (LPS)-induced PGE2 production and COX-2 expression,and blockade of NF-κB activation and translocation.In addition,Inulicin directly inhibits the binding of active NF-κB to specific DNA cis-element. 体内研究 Administration of a single dose of Inulicin (1-O-Acetylbritannilactone;12mg/kg/day) remarkably suppresses growth of A549 xenografts in nude mice.In vivo microvessels formation and Src activation are also significantly inhibited in Inulicin-treated xenograft tumors.To investigate the potential activity of Inulicin in vivo,a nude mice xenograft model is applied.A single dose of Inulicin (12mg/kg/day,i.p.) dramatically inhibits the growth of A549 xenografts in nude mice.Further,the weights of Inulicin-treated tumors are remarkably lighter than that of vehicle-treated tumors.Notably,Inulicin administration does not affect mice body weights.   推荐实验方法(仅供参考) 细胞实验:   HUVECs or A549 cells are plated in 60 mm plates (300 cells/plate).After overnight incubation,cells are treated with applied agents (e.g.,Inulicin;5μM and 10μM) for 24h.Cells are then washed,and fresh media are added.After 10 days of incubation,surviving colonies are fixed,stained,and manually counted.   动物实验:   Mice Male nude mice (4-6weeks old,BALB/c) are used.A549 cells (five million cells in 0.1mL of culture medium) are subcutaneously injected at the right thigh of nude mice,and treatment is started when the tumors reach an average volume about 100mm3.Animals are randomized into two groups with 10 mice per group:(a) Vehicle;(b) 12mg/kg of Inulicin.Inulicin is injected intraperitoneally (i.p.) daily.The mice are examined daily for toxicity/mortality relevant to treatment,and the tumor is measured with a caliper every two days.The tumor volume (in mm3) is calculated,and the tumor growth curve is presented.At the end of experiments,xenograft tumors are isolated through surgery and weighted.
保存条件：2-8℃

猜你喜欢