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雷诺嗪  ≥98%

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包装规格：1g 5g 25g 100g in glass bottle
溶解性：溶于DMSO(125mg/ml超声)
产品描述：一种抗心绞痛和抗缺血剂，可通过抑制内向钠电流的后期作用(对INa和IKr的IC50值分别为6μM和12μM)来发挥功效，而不会影响心率或血压。Ranolazine还是脂肪酸氧化(FAO)的部分抑制剂。Ranolazine is an anti-ischemic compound, which inhibits late sodium current that results in a reduction of Na+ dependent Ca2+ overload. Studies indicate that ATP production is shifted towards glucose oxidation by Ranolazine. This is due to the fact that more oxygen is required to phosphorylate the same amount of ATP during fatty acid oxidation than carbohydrate oxidation. These studies indicate that Ranolazine also inhibits oxygen consumption and ketogenesis by fatty acids in liver cells.

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