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包装规格：5mg 10mg 25mg 50mg 100mg in glass bottle
产品简介：一种抗帕金森药物和多巴胺受体激动剂。
溶解性：DMSO :63 mg/mL (199.7 mM) Ethanol：63 mg/mL (199.7 mM) Water：Insoluble
储备液保存：-80°C, 6 months -20°C, 1 month (protect from light, stored under nitrogen)
靶点：Ki: Dopamine receptor; 5-HT receptor
体外研究：Rotigotine has a 10-fold selectivity for D3 (pKi=9.2) receptors compared with D2, D4 and D5 (pKi=8.5-8.0) and a 100-fold selectivity compared with D1 receptors (pKi=7.2). In functional studies, Rotigotine behaves as full agonist at all dopamine receptors but notably the potency for stimulation of D1 receptors is similar to that for D2 and D3 receptors (pEC50?respectively: 9.0, 9.4-8.6, 9.7). Rotigotine (10 μM) decreases the number of THir neurons by 40% in primary mesencephalic cell culture. Rotigotine (0.01 μM) slightly protects dopaminergic neurons against MPP+?toxicity, significantly protects dopaminergic neurons against rotenone-induced cell death, and significantly inhibits ROS production by rotenone.
保存条件：-20°C
注意事项：1、为了您的安全和健康，请穿实验服并戴一次性手套操作。 2、以上信息仅做参考交流之用。

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