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Ro25-6981  ≥98%

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包装规格：5mg 25mg 100mg in glass bottle
溶解性：溶于DMSO(100mg/ml超声)
产品描述：一种包含NR2B亚基的NMDA受体选择性阻断剂，对于重组型NR1C/NR2B和NR1C/NR2A受体的IC50为0.009和52μM。Ro 25-6981 is a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Ro 25-6981 inhibited 3H-MK-801 binding to rat forebrain membranes in a biphasic manner with IC50 values of 0.003 microM and 149 microM for high- (about 60%) and low-affinity sites, respectively. NMDA receptor subtypes expressed in Xenopus oocytes were blocked with IC50 values of 0.009 microM and 52 microM for the subunit combinations NR1C & NR2B and NR1C & NR2A, respectively, which indicated a >5000-fold selectivity.

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