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ZL006  ≥98%

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包装规格：5mg 25mg 100mg in glass bottle
溶解性：溶于DMSO(≥5mg/ml 加热)
产品描述：NOS/PSD-95相互作用的抑制剂，可抑制nMDAreceptor诱导的一氧化氮的合成。 ZL006 is a PSD95-nNOS protein-protein interaction inhibitor. ZL006 (EC50: 12.88 μM) directly inhibited binding of purified PSD95 and nNOS proteins in AlphaScreen without altering binding of PSD95 to ErbB4. ZL006 preferentially suppressed phase 2A pain behavior in the formalin test and suppressed allodynia induced by intraplantar complete Freund's adjuvant administration. Disrupting PSD95-nNOS protein-protein interactions is effective in attenuating pathological pain without producing unwanted side effects (i.e. motor ataxia) associated with NMDAR antagonists.

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