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包装规格：2mg 5mg 10mg 25mg 50mg 100mg in glass bottle
产品简介：Clomipramine (Chlorimipramine) 有效阻断 5-HT 再摄取 (5-HT reuptake)，IC50 值为 1.5 nM。Clomipramine 是一种三环类抗抑郁药，可用于抑郁症和强迫症 (OCD) 的研究。
储备液保存：-80°C, 6 months -20°C, 1 month (protect from light)
体外研究：Clomipramine can inhibit reuptake of both noradrenaline and 5-HT, although Clomipramine inhibits 5-HT reuptake more strongly than it inhibits noradrenaline reuptake. The antidepressant Clomipramine inhibits both venom AChE as well as human serum BChE in a concentration-dependent manner but has no effect on AChE in the rat brain striatum. Clomipramine interferes with the autophagic flux and severely compromises the viability of tumorigenic cells upon cytotoxic stress. Clomipramine reduces autophagy in neuronal primary cultures. Clomipramine (1 and 5 µM) negatively regulates neuronal autophagic pathway in primary cultured cells.
体内研究：Clomipramine (5-20 mg/kg; i.p) elicits significant hyperglycemia in mice. Clomipramine induces hyperglycemia in mice by blocking the 5-HT2B and/or 5-HT2C receptors, which results in facilitation of adrenaline release. In mice, Clomipramine reduces immobility in the forced swimming test, which is the behavioral model for antidepressants. Clomipramine also inhibits the OCD animal model, marble burying behavior in mice. Clomipramine (20 mg/kg) decreases autophagic flux in murine tissues.
保存条件：-20°C
注意事项：1、为了您的安全和健康，请穿实验服并戴一次性手套操作。 2、以上信息仅做参考交流之用。

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