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Guanabenz HCl  ≥98%

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包装规格：5mg 10mg 25mg 50mg 100mg in glass bottle
产品简介：Guanabenz hydrochloride 是一种 α-2 肾上腺素受体激动剂，具有口服活性。Guanabenz hydrochloride 具有抗高血压和抗寄生虫活性。Guanabenz hydrochloride 干扰内质网应激信号传导，对心肌细胞具有保护作用。Guanabenz hydrochloride 也被用于高血压的研究。
储备液保存：-80°C, 6 months -20°C, 1 month (sealed storage, away from moisture and light)
靶点：Toxoplasma
体外研究：Guanabenz hydrochloride(0.5-50μM, 24 h) is treated with increasing concentrations for 24 hours not affect cell viability. Guanabenz hydrochloride(0.5-50μM, 24 h) alone not affects the UPR targets,neither on mRNA or protein level nor the phosphorylation status of eIF2a.Guanabenz also not induces GADD34 or the constitutively active form CReP. Guanabenz hydrochloride(0.5-50μM, 24 h) alone not induces ER stress in neonatal rat cardiomyocytes.
体内研究：Guanabenz hydrochloride (5 mg/kg/day; i.p.; for 3 weeks) can reproducibly reduce brain cyst burden. Guanabenz hydrochloride (5 mg /kg/d, i.p., oral; 10 mg/kg/d, gavage; for 3 weeks) reverses Toxoplasma-induced hyperactivity in latently infected mice. Guanabenz hydrochloride (100 and 320 μg/kg and 1 mg/kg, i.v., over a period of 5 min at intervals of 40 min) reduces sympathetic outflow, heart rate and blood pressure in debuffered cats.
保存条件：2-8°C 密封干燥 避光
注意事项：1、为了您的安全和健康，请穿实验服并戴一次性手套操作。 2、以上信息仅做参考交流之用。

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