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包装规格：1mg 5mg 25mg 100mg in glass bottle
产品简介：Semaglutide 是人胰高血糖素样肽-1 的一个长效类似物， 是人胰高血糖素样肽-1 (GLP-1) 受体的激动剂。Semaglutide 有潜力用于 2 型糖尿病的研究。
溶解性：DMSO :5 mg/mL (1.22 mM; ultrasonic and warming and heat to 60°C) Water：12.5 mg/mL (3.04 mM; ultrasonic and adjust pH to 2 with HCl)
储备液保存：-80°C, 6 months -20°C, 1 month (sealed storage, away from moisture)
靶点：GLP-1 receptor
体外研究：Semaglutide has two amino acid substitutions compared to human GLP-1 (Aib8, Arg34) and is derivatized at lysine 26. The GLP-1R affinity of Semaglutide is 0.38±0.06 nM. Semaglutide is a GLP-1 analogue with 94% sequence omology to human GLP-1.
体内研究：The plasma half-life of Semaglutide is 46h in mini-pigs following i.v. administration and semaglutide has an MRT of 63.6h after s.c. dosing to mini-pigs. Semaglutide improves 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-induced motor impairments. In addition, Semaglutide rescues the decrease of tyrosine hydroxylase (TH) levels, alleviates the inflammation response, reduces lipid peroxidation, inhibits the apoptosis pathway, and also increases autophagy- related protein expression, to protect dopaminergic neurons in the substantia nigra and striatum. Moreover, the long-acting GLP-1 analogue semaglutide is superior to NN-2211 in most parameters.
保存条件：-20°C
注意事项：1、为了您的安全和健康，请穿实验服并戴一次性手套操作。 2、本产品为钠盐形式。 3、以上信息仅做参考交流之用。

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