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NS1652  ≥98%

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包装规格：1mg in glass bottle
溶解性：溶于DMSO（5mg/ml超声)
产品描述：基本信息 产品编号： N11027 产品名称： NS1652 CAS: 1566-81-0   储存条件 粉末 -20℃ 四年     分子式： C15H11F3N2O3 溶于液体 -80℃ 6个月 分子量： 324.25 -20℃ 1个月 化学名：  Benzoic acid,2-((((3-(trifluoromethyl)phenyl)amino)carbonyl)amino)- Solubility (25°C)：   体外:   DMSO   Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 3.0840mL 15.4202mL 30.8404mL 5mM 0.6168mL 3.0840mL 6.1681mL 10mM 0.3084mL 1.5420mL 3.0840mL   生物活性 产品描述 一种可逆的阴离子电导(anionconductance)抑制剂 靶点 IC50:1.6μM (chloride channel,human and mouse red blood cell)   体外研究 NS1652 potently inhibits the chloride conductance (IC50,1.6μM) in human and mouse red blood cells,but only weakly inhibits VRAC (IC50,125μM) in HEK293 cells.NS1652 markedly blocks the NO production with an IC50 of 3.1μM in BV2 cells.NS1652 also down-regulates iNOS expression at 3μM,and completely abolishes at 10μM in BV2 cells.NS1652 (0,1.0,3.3,10,and 20μM) causes increasing hyperpolarization due to inhibition of the chloride conductance in normal erythrocytes.NS1652 lowers the net KCl loss from deoxygenated sickle cells from about 12mM cells/h to about 4mM cells/h.NS1652 (20μM) completely and reversiblely inhibits the red cell Cl-conductance. 体内研究 NS1652 (50mg/kg,i.v.) blocks murine erythrocyte Cl- conductance by >90% in mice.   推荐实验方法(仅供参考) 动物实验:   NS1652 is suspended in a carrying vehicle, cremophore (pig-40 hydrogenated castor oil),at a concentration of 5mg/mL.At time zero,an amount corresponding to 1% of animal weight (about 250μL of suspension) is injected into mice though the tail veins (NMRI strain,5-6 weeks).At several time intervals after the injection,the mice are decapitated and the blood collected is collected and centrifuged for 60 seconds.The plasma is removed by aspiration and the packed cells are stored on ice until use.Immediately before measurement,the packed cells are resuspended in 1 volume of ice-cold experimental medium and centrifuged for 30 seconds.A total of 100μL of packed cells are then immediately transferred to 3mL medium,and CCCP and valinomycin added.The blood samples are analyzed in random order with respect to the time of decapitation.
保存条件：-20℃

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