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CGP 65015  

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包装规格：1mg in glass bottle
产品描述：基本信息 产品编号： C11720 产品名称： CGP 65015 CAS: 189564-33-8   储存条件 粉末 -20℃ 四年     分子式： C14H15NO4 溶于液体     分子量 261.27     化学名：  3-Hydroxy-1-(2-hydroxyethyl)-2-(hydroxyphenylmethyl)-4(1H)-pyridinone   生物活性 产品描述 一种可口服的铁螯合剂，可以清除铁沉积。 靶点   体外研究 CGP 65015 is an oral iron chelator 体内研究 CGP65015 (150μmol IBE/kg p.o. on d0) dramatically increases the urinary and faecal iron clearance, and still enhances iron elimination during the second post-treatment day in iron-overloaded marmosets   推荐实验方法(仅供参考) Animal Administration Marmosets To approximate the iron status of thalassaemic patients in the marmosets, the animals are iron-overloaded by three i.p. injections of iron (III) hydroxide polyisomaltose at 14-d intervals (200mg/kg twice and 100mg/kg at the third injection). Prior to the first exposure to an iron chelator (CGP 65015), the marmosets are rested for at least 8 weeks in order to allow definite distribution of the injected iron into all storage compartments. CGP 65015 is dispersed in 40% aqueous Cremophor RH 40 for oral administration of 150μmol IBE/kg. All dosages are expressed in terms of 'iron binding equivalents' (IBE) which take into account the stoichiometry of the chelator in the iron complex, i.e. 150μmol IBE correspond to 150, 300 and 450μmol of a mono-, bi- and tridentate chelator respectively. The standard dose is 150μmol iron binding equivalents (IBE) per kg body weight. The applied volume is 5 mL/kg body weight
保存条件：-20°C

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