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二甲他林  ≥95%

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包装规格：1g in glass bottle
产品描述：基本信息 产品编号： D11701 产品名称： Dimetacrine CAS: 4757-55-5   储存条件 粉末 -20℃ 四年     分子式： C20H26N2 溶于液体     分子量 294.43     化学名：  9,9-Dimethyl-10-(3-(dimethylamino)propyl)acridan   生物活性 产品描述 一种有用的抗抑作用，可用于各种类型的抑郁症的研究。 体内研究 Dimetacrine is a useful antidepressant which can be used for the treatment of various types of depression. Dimetacrine in the highest concentration, 10μM, decreases the contractile force to 36.5±9.1%. Dimetacrine, 0.3μM, causes no statistically significant decline in contractile force from the controls. Tachycardia is observed after the administration of Dimetacrine, 1 to 3mg/kg i.v., and the maximum response is obtained in dose of 3mg/kg i.v.. The administration of Dimetacrine, 30mg/kg i.v., causes an abrupt fall in blood pressure with tachycardia or bradycardia followed by cardiac arrest. Respiratory rate increases 40 min after the onset of infusion of Dimetacrine. Arterial blood pressure falls 50 min after the onset of infusion of Dimetacrine   推荐实验方法(仅供参考) Animal Administration Adult male mongrel dogs weighing 8 to 13 kg are used and anesthetized with sodium pentobarbital, 35mg/kg i.v. Respiratory movement is measured by an accordion-type pneumograph placed around the thoraco-abdominal region and a pressure transducer. For the experiments on single i.v. injections, the increasing doses of Dimetacrine, 0.1, 0.3, 1, 3, 10 and 30mg/kg i.v., until cardiac arrest occurs, are given into the cannulated left cephalic vein and are flushed with 1mL of physiological saline. The changes in arterial blood pressure and heart rate caused by each dose are estimated for IMP, AMT and Dimetacrine
保存条件：-20°C

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