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比莫西糖二钠盐  

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包装规格：1g in glass bottle
产品描述：基本信息 产品编号： B11747 产品名称： Bimosiamose disodium CAS: 187269-60-9   储存条件 粉末 -20℃ 四年     分子式： C46H52Na2O16 溶于液体     分子量 906.88     化学名：  (1,1'-Biphenyl)-3-acetic acid,3',3'''-(1,6-hexanedidyl)bis(6'- (alpha-D-mannopyranosyloxy)-, disodium salt   生物活性 产品描述 一种非寡糖泛-selectin 抑制剂。Bimosiamose disodium 具有抗炎作用。 靶点 IC50: 88μM (E-selectin), 20μM (P-selectin), and 86μM (L-selectin) 体外研究 Bimosiamose (TBC-1269) operates by inhibiting neutrophil recruitment to the site of inflammation through blocking the initial rolling phase of recruitment. Bimosiamose (TBC-1269) inhibits cell recruitment and does not possess any cytotoxic effect on neutrophils 体内研究 Bimosiamose (TBC-1269; 25mg/kg; intravenous injection; Sprague-Dawley rats) treatment shows a significant increase in survival. Best overall survival, 70%, is observed when TBC-1269 is administered 15 minutes before reperfusion, and also shows a marked decrease in liver enzyme levels at 6 hours after reperfusion. Neutrophil migration is also significantly ameliorated (81%). The histologic damage scores is also improved Animal Model: Sprague-Dawley rats (200-225g) with ischemia and reperfusion (I/R) Dosage: 25mg/kg Administration: Intravenous injection Result: Showed a significant increase in survival compared with controls.
保存条件：-20℃

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