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> 3,3'-((4-甲氧基苯基)亚甲基)双(1H-吲哚)
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3,3'-((4-甲氧基苯基)亚甲基)双(1H-吲哚)  ≥98%

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包装规格：5mg 25mg 100mg in glass bottle
溶解性：溶于DMSO（≥30mg/mL）
产品描述：基本信息 产品编号： D11343 产品名称： DIM-C-pPhOCH3 CAS: 33985-68-1   储存条件 粉末 -20℃ 四年     分子式： C24H20N2O 溶于液体 -80℃ 两年 分子量 352.43 -20℃ 一个月 化学名：  3,3'-[(4-methoxyphenyl)methylene]bis-1H-Indole Solubility (25°C)：   体外:   DMSO 70mg/mL (198.62mM) Ethanol 5mg/mL (14.18mM) Water Insoluble 体内(现配现用): 1.请依序添加每种溶剂：10% DMSO→40% PEG300→5% Tween-80→45% saline Solubility: ≥ 2.5mg/mL (7.09mM); Clear solution 此⽅案可获得 ≥ 2.5mg/mL (7.09mM，饱和度未知) 的澄清溶液。 以 1mL ⼯作液为例，取 100μL 25.0mg/mL 的澄清 DMSO 储备液加到 400μL PEG300 中，混合均匀；向上述体系中加⼊ 50μL Tween-80，混合均匀；然后继续加⼊ 450μL ⽣理盐⽔定容⾄ 1mL。 2.请依序添加每种溶剂：10% DMSO→90% (20% SBE-β-CD in saline) Solubility: ≥ 2.5mg/mL (7.09mM); Clear solution 此⽅案可获得 ≥ 2.5mg/mL (7.09mM，饱和度未知) 的澄清溶液。 以 1mL ⼯作液为例，取 100μL 25.0mg/mL 的澄清 DMSO 储备液加到 900μL 20% 的 SBE-β-CD ⽣理盐⽔⽔溶液中，混合均匀。 ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 2.8374mL 14.1872mL 28.3744mL 5mM 0.5675mL 2.8374mL 5.6749mL 10mM 0.2837mL 1.4187mL 2.8374mL 50mM 0.0567mL 0.2837mL 0.5675mL   生物活性 产品描述 一种 Nur77 激动剂。Nur77 是一种孤儿核受体。 靶点 Nur77 () 体外研究 DIM-C-pPhOCH3 decreases survival and induces apoptosis in RKO colon cancer cells, and this is accompanied by induction of tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) protein. DIM-C-pPhOCH3 also induces Nur77- independent apoptosis. DIM-C-pPhOCH3 (10μM) inhibits cell growth after treatment for 24, 48, or 72 h, and the maximum inhibitory response is observed after 72 h, where there is considerable cell detachment and dead cells. The growthinhibitory effects observed for DIM-C-pPhOCH3 after 72 h are also accompanied by several markers of apoptosis, including PARP cleavage and cleavage of caspase-3, caspase-9, and caspase-8. PARP cleavage is also observed after treatment of RKO cells for 48 h with DIM-C-pPhOCH3 体内研究 DIM-C-pPhOCH3 (25mg/kg/d) also inhibits tumor growth in athymic nude mice bearing RKO cell xenografts. The effects of DIM-C-pPhOCH3 (25mg/kg/d) on colon tumor growth are also investigated in athymic nude mice bearing RKO cell xenografts. Treatment with the DIM-C-pPhOCH3 significantly decreases tumor volumes and final tumor weights compared with corn oil controls   推荐实验方法(仅供参考) Cell Assay RKO cells are treated with DMSO or 12.5μM DIM-C-pPhOCH3 for 2 and 6 h. RNA is isolated for the reverse transcription-PCR (RT-PCR) experiment and analyzed for gene expression, and three replicates are determined for each time point and the DMSO control. The microarray data are analyzed     Animal Administration Mice Male athymic nude mice (Foxn1nu, ages 7-8 weeks) are used. The mice are housed and maintained in laminar flow cabinets under specific pathogen-free conditions. A xenograft is established by s.c. injection of in vitro cultured RKO cells (5×106 per 150μL) into the flanks of individual mice. Tumors are allowed to grow for 4 days until tumors are palpable. Mice are then randomized into two groups of six mice per group and dosed by oral gavage with either corn oil or 25mg/kg/d DIM-CpPhOCH3 for 21 days. The mice are weighed, and tumor size is measured
保存条件：-20℃

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