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SR3335  ≥98%

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包装规格：5mg 10mg 50mg in glass bottle
溶解性：溶于DMSO(≥100mg/mL)
产品描述：一种选择性的 RORα 反向激动剂，可直接结合 RORα，Ki为 220 nM。SR3335, also known as ML 176, is a RORα selective inverse agonist. SR3335 directly binds to RORα, but not other RORs, and functions as a selective partial inverse agonist of RORα in cell-based assays. Furthermore, SR3335 suppresses the expression of endogenous RORα target genes in HepG2 involved in hepatic gluconeogenesis including glucose-6-phosphatase and phosphoenolpyruvate carboxykinase. SR3335 can be utilized as a chemical tool to probe the function of this receptor both in vitro and in vivo. SR3335 may hold utility for suppression of elevated hepatic glucose production in type 2 diabetics.
保存条件：-20℃

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