MF-438  ≥98%

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包装规格:5mg 10mg 25mg in glass bottle
溶解性:溶于DMSO(10mg/mL 超声)
产品描述:一种有效且口服生物可利用的 stearoyl-CoA desaturase 1 (SCD1) 的抑制剂,对 rSCD1 的 EC50 值为 2.3 nM。MF-438 is a potent and orally bioavailable SCD inhibitor. MF-438 exhibits good pharmacokinetics and metabolic stability, thereby serving as a valuable tool for further understanding the role of SCD inhibition in biological and pharmacological models of diseases related to metabolic disorders. Co-treatment with cisplatin and MF-438 reverts upregulation of CSCs markers, strongly synergizes in the inhibition of 3D spheroids formation and induces CSCs apoptosis.
保存条件:-20℃