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DHODH-IN-15  

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包装规格：100mg in glass bottle
产品描述：基本信息 产品编号： D11110 产品名称： DHODH-IN-15 CAS: 1364791-88-7   储存条件 粉末 -20℃ 四年     分子式： C15H11N3O3 溶于液体     分子量 281.27     化学名：      生物活性 产品描述 一种 A771726 的 hydroxyfurazan 类似物。DHODH-IN-15 是一种二氢乳清酸脱氢酶 (DHODH) 抑制剂，对大鼠肝脏 DHODH 的 IC50 为 11μM。DHODH-IN-15 可用于类风湿关节炎。 靶点 IC50: 11μM (Rat liver DHODH) 体外研究 DHODH-IN-15 (Compound 7b) is a hydroxyfurazan analog of A771726, in which the biphenyl scaffold does not bear any substituent. Moving to derivatives DHODH-IN-15, no major differences were observed among the poses obtained on 1UUO and 1D3G; in both cases DHODH-IN-15 is found to bind in a BQN-like fashion, namely with the deprotonated hydroxyfurazan moiety facing Arg136, thus effectively mimicking the carboxyl group of BQN and related compounds. While on 1D3G and 1UUO the hydroxyfurazan is in no case found to interact with Tyr356 in a Leflunomide-like fashion, a significant fraction of such poses is found when 2BXV is used as the docking target
保存条件：-20℃

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