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3-甲基亚磺酰丙基异硫氰酸酯  ≥98%

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包装规格：1mg 5mg 10mg 25mg 50mg 100mg in glass bottle
溶解性：溶于DMSO(≥310mg/mL）
产品描述：基本信息 产品编号：I10394 产品名称：1-Isothiocyanato-3-(methylsulfinyl)propane CAS: 505-44-2   储存条件   溶于液体   -20℃   两年 分子式： C5H9NOs2 分子量 163.26 化学名：      Solubility (25°C)   体外 DMSO   Ethanol   Water   体内（现配现用）     ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   生物活性 产品描述 萝卜硫素的亚砜类似物，是天然存在的异硫氰酸酯家族的成员。抑制 HL60 细胞的 IC50 值为 2.3μM。Iberin 诱导凋亡 (apoptosis)。 靶点/IC50 Human Endogenous Metabolite 体外研究 Iberin inhibits the growth of neuroblastoma cells in a dose- and time-dependent manner. The iberin-induced cell cycle arrest in neuroblastoma cells is associated with inhibition of expression of cyclin-dependent kinase Cdk2, Cdk4, and Cdk6 proteins. There is an increase in apoptotic cell death in iberin treated cells as compared with control cells. The iberininduced apoptosis is found to be associated with activation of caspase-9, caspase-3, and PARP. Iberin inhibits growth of human glioblastoma cells in cell proliferation assays, enhances cytotoxicity, and induces apoptosis by activation of caspase-3 and caspase-9. 体内研究 Iberin is tested in an in vivo foreign-body infection mouse model, and the results show no significantly difference in bacterial clearance between treated and nontreated miced. Iberin increases tissue levels of the phase II detoxification enzymes quinone reductase and glutathione S-transferase in a variety of rat tissues.   推荐实验方法(仅供参考) 细胞实验:   Cells are plated at a density of 1×105 cells/well in microtiter plates and treated with different concentrations of iberin (1, 2.5,10 and 25μM). Then 20μL of 5mg/mL MTT in PBS, is added to each well and allowed to incubate for a further 4h. After 4h of incubation, 100μL of DMSO is added to each well to dissolve the formazan crystals. Absorbance values at 550 nm are measured with a microplate reader.     动物实验:   Rats: Groups of five rats are dosed by oral intubation with the test compounds, as solutions in soybean oil, each day for 5 days. This doses used are 4.0mg/kg/day for AITC, 5.9mg/kg/day for iberverin, 6.5mg/kg/day for iberin, 6.4mg/kg/day for erucin, 7.1mg/kg/day for sulforaphane, and 7.2mg/kg/day for cheirolin. The volume of solution administered is 2mL/kg in all cases. Ten control rats are dosed with soybean oil alone.
保存条件：-20℃

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