生物试剂
>
生化试剂
>
信号通路
> CP-471474
加入收藏 取消收藏

CP-471474  ≥97%

促销价¥{{model.attbuying.price}}

市场价¥0.00

累计销量0 累计评价0 人评论

别称 {{model.alias}}
中文名称 {{model.name}}
英文名称 {{model.enname}}
品牌 {{model.brand}}
CAS {{model.cas}}
分子式
分子量 {{model.molecularweight}}
MDL {{model.mdl}}
货号 {{model.procode}}
数量

+ -

件 库存{{model.attbuying.number}}件
立即购买 加入购物车 下载说明书

看了又看
包装规格：5mg 25mg 100mg in glass bottle
溶解性：溶于DMSO(≥20mg/mL)
产品描述：基本信息 产品编号： C70139 产品名称： CP-471474 CAS: 210755-45-6   储存条件 粉末 -20℃ 四年     分子式： C16H17FN2O5S 溶于液体     分子量 368.38     化学名：  2-[[[4-(4-Fluorophenoxy)phenyl]sulfonyl]amino]-N-hydrox y-2-methylpropanamide   生物活性 产品描述 一个口服有效的、广泛的MMP抑制剂。 靶点 MMP-2 0.7nM(IC50) MMP-13 0.9nM(IC50) MMP-9 13nM(IC50) MMP-3 16nM(IC50) MMP-1 1170nM(IC50) 体外研究   体内研究 CP-471474 plasma levels following subcutaneous injection are 2,020ng/mL (1 h postdose) to 160ng/mL (6 h postdose). CP-471,474 significantly reduces both the extent and severity of inflammation at 2 months. At 4 months, a spontaneous reduction of the inflammatory response is observed in both treated and untreated animals, and consequently no difference is observed between both. CP-471474 significantly decreases the destructive lesions mainly at 2 months and also at 4 months Animal Model: Guinea pigs weighing 400 to 450 g (COPD) Dosage: 20 mg/kg (also supplemented daily by the diet (200 mg/200 g powdered chow)). Administration: Subcutaneously (in 20% ethanol/80% polyethylene glycol), once a day during the entire course. Result: Lungs derived from smoking animals treated with the compound demonstrated a statistically significant reduction in the destructive lesions.Showed an increase of both pro–MMP-9 and its active form (lanes 5 to 8) as compared with control animals.
保存条件：-20℃

猜你喜欢