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Pumaprazole  

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包装规格：5mg in glass bottle
产品描述：基本信息 产品编号： P11296 产品名称： Pumaprazole CAS: 158364-59-1   储存条件 粉末 -20℃ 四年     分子式： C19H22N4O2 溶于液体 -80℃ 6个月 分子量： 338.40 -20℃ 1个月 化学名：  Methyl 2-(((2,3-dimethylimidazo(1,2-a)pyridin-8-yl)amino)methyl)-3-methylcarbanilate Solubility (25°C)：   体外:   DMSO   Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 2.9551mL 14.7754mL 29.5508mL 5mM 0.5910mL 2.9551mL 5.9102mL 10mM 0.2955mL 1.4775mL 2.9551mL   生物活性 产品描述 一种可逆性质子泵拮抗剂。 靶点 proton pump 体内研究 Pumaprazole is a reversible proton pump antagonist.Basal acid secretion in the Ghosh-Schild rat is inhibited by Pumaprazole with a higher efficacy compare to ranitidine.Pumaprazole displays identical ID50 values on day 1 (11μmol/kg,95% confidence limits of 5 and 23) and on day 7 (10μmol/kg,95% confidence limits of 4 and 23) of a repeated dose study in this model.The lower dose of Pumaprazole (27μmol/kg) rapidly elevates luminal pH up to almost neutrality,the higher dose (54μmol/kg) further prolongs this pH-elevating effect.   推荐实验方法(仅供参考) 动物实验:   The pylorus of female Sprague-Dawley rats (160 to 220g body weight) is ligated under ether anesthesia,the abdomen is closed and 100mg/kg of acetylsalicylic acid (ASA) in 10mL/kg are given orally.Following ASA administration,Pumaprazole (solution) or vehicle (i.v.saline or tap water in case of oral administration) is given i.v.in 1mL/kg or i.d.in 2.5mL/kg.Oral drug administration (in 10mL/kg) is 1h before pylorus ligation.Four hours after pylorus ligation,the stomach is excised,carefully keeping the esophagus closed,opened along the greater curvature and the luminal contents are removed,centrifuged,the volume is measured and the acidity determined by titration with 0.1 N NaOH to pH 7.
保存条件：-20℃

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