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Teglarinad chloride  ≥98%

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包装规格：5mg in glass bottle
溶解性：溶于DMSO(100mg/ml 超声)
产品描述：一种烟酰胺磷酸核糖基转移酶抑制剂)的前药。在小鼠中表现出抗肿瘤活性可以归因于NAMPT的抑制。通过干扰DNA修复和抗血管生成，可以增强放射功效。Teglarinad chloride, also known as GMX-1777 and EB1627, is a potent NAMPT inhibitor. GMX1777 is a water-soluble prodrug of the cyanoguanidine compound GMX1778 with potential antineoplastic activity. In vivo, apoptosis inducer GMX1777 is rapidly converted into GMX1778 through hydrolytic cleavage of a carbonate ester bond. Although the exact mechanism of action has yet to be fully elucidated, GMX1778 appears to antagonize nuclear factor-kappa B (NF-kB) transcription, resulting in the induction of tumor cell apoptosis.
保存条件：-20℃

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