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NS3623 促销  ≥98%

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包装规格：5mg 25mg 100mg in glass bottle
溶解性：溶于DMSO(2mgmL)
产品描述：基本信息 产品编号： N11053  产品名称： NS3623 CAS: 343630-41-1   储存条件 粉末 -20℃ 四年     分子式： C15H10BrF3N6O 溶于液体 -80℃ 6个月 分子量： 427.18 -20℃ 1个月 化学名：  N-[4-Bromo-2-(2H-tetrazol-5-yl)phenyl]-N′-[3-(trifluoromethyl)phenyl]urea,NS 3623,1-(3-Trifluoromethylphenyl)-3-[2-(1H-tetrazol-5-yl)-4-bromophenyl]urea Solubility (25°C)：   体外:   DMSO   Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   生物活性 产品描述 一种hERG1(KV11.1)钾通道的激活剂。NS3623激活IKr和Ito电流，具有抗心律失常作用。NS3623具有双重作用模式，也是hERG1通道的抑制剂。 靶点 Potassium Channel   体外研究 In isolated canine cardiomyocytes,application of NS3623 (5μM) greatly increases the size of the tail current confirming previous studies demonstrating this drug increased IKr.The effect of NS3623 on IKr recorded from cells kept in culture is evaluated.After 48h,the magnitude of IKr is greatly reduced compared to freshly isolated cells.Peak IKr tail currents are 0.47±0.08 pA/pF in freshly isolated myocytes and 0.28±0.06 pA/pF in 2 day cultured myocytes. Application of NS3623 increases IKr in cultured Mid cells.Analysis of the current-voltage (I-V) relation of IKr tail current showed that NS3623 increased current density in both 1 day and 2 day cultured Mid cells.On a percentage basis,NS3623 increases IKr tail currents (at +50mV activating pulse) by 60% in normal Mid cells,and 68% in 48h cultured cells. 体内研究 NS3623 (30mg/kg;i.v.;lasting for 3 minutes) shortens the corrected QT interval by 25+/-4% in anaesthetized guinea pigs.NS3623 (50mg/kg) shortenes the QT interval by 30+/-6% in conscious guinea pigs.NS3623 (50mg/kg) immediately decreases the QTcF interval and remains significantly shortened for approximately 30 minutes. Animal Model: Anesthetized guinea pig Dosage: 30mg/kg Administration: Intravenous injection;lasting for 3 minutes Result: Shortened the corrected QT interval by 25+/-4%.
保存条件：-20℃

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