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Progabide  

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包装规格：5mg in glass bottle
产品描述：基本信息 产品编号： P11267 产品名称： Progabide CAS: 62666-20-0   储存条件 粉末 -20℃ 四年 分子式： C17H16ClFN2O2 溶于液体 -80℃ 一年 分子量： 334.77     化学名：  4-[[(E)-(4-chlorophenyl)-(3-fluoro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]butanamide Solubility (25°C)：   体外:   DMSO   Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   生物活性 产品描述 一种γ-氨基丁酸(GABA)受体激动剂。 靶点 GABA receptor 体内研究 Progabide is a gamma-aminobutyric acid receptor (GABA) agonist.Doses of 50,100 and 200mg/kg Progabide given IP to male Wistar rats increase the plasma corticosterone levels by 244,365 and 476% respectively (t=6.44 to12.55,p<0.01).10mg/kg of Progabide fails to change the concentration of corticosterone in plasma (t=0.76,N.S.).The increased plasma corticosterone level induced by administration of 200mg/kg Progabide is evident 30 (t=2.625,p<0.05),60 (t=13.13,p<0.001) and 120 min (t=4.07,p<0.01) after drug injection,but returns to the control value 240 min after drug injection (t=0.86,N.S.).The greatest corticosterone rise (compare with the corresponding control) is reached 60 min following the administration of Progabide.   推荐实验方法(仅供参考) 动物实验:   Male Wistar rats weighing 170 to 240g are caged in groups of three under diurnal lighting conditions with free access to food and water.The rats are accustomed to handling (housing 1 per cage for 30 min,injecting with saline,1mL/100g body weight) in the period of 7 days before the beginning of the experiment. Progabide is injected as a suspension in saline containing 0.1% Tween 80.Control rats are treated IP with the corresponding vehicle (1mL/100g body weight). Ether stress is performed and 15 min after the beginning of the stressful procedure the animals are sacrificed.
保存条件：-20℃

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