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异四氢烟酸  ≥98%

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包装规格：250mg 1g 5g in glass bottle
溶解性：溶于(DMSO25mg/ml超声)
产品描述：基本信息 产品编号： I70042 产品名称： Isoguvacine hydrochloride CAS: 68547-97-7   储存条件 粉末 2-8℃ 四年     分子式： C6H10ClNO2 溶于液体 -80℃ 6个月 分子量： 163.60 -20℃ 1个月 化学名：  1,2,3,6-Tetrahydropyridine-4-carboxylic Acid Hydrochloride一种GABA受体激动剂。 Solubility (25°C)：   体外:   DMSO   Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 6.1125mL 30.5623mL 61.1247mL 5mM 1.2225mL 6.1125mL 12.2249mL 10mM 0.6112mL 3.0562mL 6.1125mL   生物活性 产品描述 一种GABA受体激动剂。 靶点 GABA   体外研究 Isoguvacine binds to a mouse forebrain synaptic membrane preparation.The specific binding is displaceable by GABA,muscimol and bicuculline but not by picrotoxin or diaminobutyric acid.Kinetic data suggest two binding affinities.Highest levels of binding are observed in the cerebellum,cortex and hippocampus.Isoguvacine binds to membrane preparations of rat forebrain with pharmacological characteristics similar to the postsynaptic GABA recognition site:that it is transported into synaptosomal preparations by an uptake system similar to the high-affinity GABA uptake system;and that recently accumulated isoguvacine is released in a Ca2+-dependent manner and by heteroexchange with external GABA.Isoguvacine at a concentration of 50μM blocks the seizure like events in 2 out of 6 organotypic hippocampal slice cultures.Isoguvacine inhibits the low magnesium induced seizure like events dose dependently.   推荐实验方法(仅供参考) 激酶实验： The assay for 3H-Isoguvacine binding is carried out as follows:membranes suspended in Tris-citrate buffer pH 7.1 are incubated at 4℃ for 10 min with 8nM 3H-Isoguvacine.Identical samples are incubated in the presence of cold 0.5mM GABA or 10μM cold isoguvacine.The assay is terminated by centrifugation for 10 min at 4℃ in a micro-centrifuge.The supernatants are rapidly aspirated and the surface of the pellets washed (2x) with ice-cold buffer.The pellet is resuspended in I00μL of 0.1% Triton and placed in a scintillation vial.The assay tube is washed with I00μL of distilled water and the wash added to the vial along with 10ml of PCS:xylene (2:1).Counting efficiency is determined to be 40-45% in a Beckman liquid scintillation counter.Specific binding is defined as those radioactive cpm of bound 3H-Isoguvacine that are displaced by excess cold isoguvacine or GABA.
保存条件：2-8℃

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