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托泊地芬  

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包装规格：25mg 50mg 100mg in glass bottle
产品描述：基本信息 产品编号： T10844 产品名称： Tropodifene CAS: 15790-02-0   储存条件 粉末 -20℃ 四年 分子式： C25H29NO4 溶于液体 -80℃ 二年 分子量 407.50      化学名：  3-(p-Acetyloxyphenyl)-2-phenylpropionic acid (1S,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3alpha-yl ester Solubility (25°C)：   体外:   DMSO   Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   生物活性 产品描述 一种α-肾上腺素能受体 (α-Adrenergic receptor) 抑制剂。 靶点 α-Adrenergic 体内研究 Tropaphen has a beneficial effect on hypertension.The therapeutic effect of this preparation is more constant in diseases accompanied by spasm of the peripheral vessels.Tropaphen has a very marked adrenolytic and vasodilator action.It greatly lowers the tone of the peripheral vessels.The preparation is effective starting with a dose of 0.1mg/kg.After injection of the drug in a dose of 0.25mg/kg,a considerable and gradually progressive decrease in the perfusion pressure takes place.The pressure falls by 30-35% and remained at a low level for 90-100 min.With a dose of tropaphen of 0.5mg/kg,the perfusion pressure falls by 40-45% and remains low for 120 min or more.Strong vasodilatation is also observed after injection of tropaphen into intact rabbits.   推荐实验方法(仅供参考) 动物实验:   Rabbits The drug is injected intravenously into rabbits.Experiments on the isolated ears of the rabbits are carried out by the Kravkov--Pisemskii method.The effect of tropaphen on the ear vessels of the intact rabbit is judged by the changes in the temperature of the ear.The temperature is measured by means of an electrothermometer,the detector of which is fixed to the internal surface of the ear.The dilation of the auricular vessels is also examined under the microscope,observations being made on the lumen of the marginal artery and vein.
保存条件：-20℃

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