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TFEB activator 1  ≥98%

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包装规格：5mg 25mg 100mg in glass bottle
溶解性：溶于DMSO（125 mg/mL 超声）
产品描述：基本信息 产品编号：T10756 产品名称：TFEB activator 1 CAS: 39777-61-2   储存条件 粉末 -20℃ 四年 分子式： C19H18O3 4℃ 两年 分子量 294.34 化学名：  (1E,4E)-1,5-Bis(2-methoxyphenyl)penta-1,4-dien-3-one   Solubility (25°C)   体外 DMSO 100mg/mL (339.74mM; Need ultrasonic) Ethanol   Water   体内 现配现用   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 3.3974mL 16.9872mL 33.9743mL 5mM 0.6795mL 3.3974mL 6.7949mL 10mM 0.3397mL 1.6987mL 3.3974mL   生物活性 产品描述 一种口服有效的，不依赖 mTOR 的 TFEB 激活剂。TFEB activator 1 显着促进 Flag-TFEB 的核易位，EC50 为 2167nM。 靶点/IC50 Flag-TFEB nuclear translocation EC50: 2167nM   体外研究 TFEB activator 1 (Compound C1) activates TFEB (transcription factor EB) by directly binding to TFEB and promotes its entry into the nucleus, without affecting TFEB phosphorylation or inhibiting the activities of MTOR and MAPK1/ERK2-MAPK3/ERK1. TFEB activator 1 (1μM; for 12 h) significantly increases the levels of LC3B-II, the lipidated and phagophore- or autophagosome-associated form of MAP1LC3B/LC3B (microtubule-associated protein 1 light chain 3 β) in N2a cells. TFEB activator 1 (0.2-1μM) dose-dependently increases the levels of LC3-II and SQSTM1/p62 (sequestosome 1) in N2a cells. Western Blot Analysis Cell Line: N2a cells Concentration: 0, 0.2, 0.4, 0.6, 0.8 and 1μM Incubation Time: 12 hours Result: Treatment dose-dependently increased the levels of LC3-II and SQSTM1/p62 (sequestosome 1).   体内研究 The medium lethal dose (LD50) value of TFEB activator 1 (Compound C1) is 175 mg/kg in the acute toxicity assay (single-dose i.v. tail vein injection; in rats) . Short-term oral administration of TFEB activator 1 (low dosage 10mg/kg and high dosage 25mg/kg; for 24 h) dosedependently increases the expression of LC3B-II and TFEB in the liver, frontal cortex and striatum of the brain. Chronic administration of TFEB activator 1 (10mg/kg per day; orally administered by gavage) activates TFEB and enhances autophagy in rat brains Animal Model: Adult male Sprague-Dawley (SD) rats weighing 350 to 400g Dosage: 10mg/kg and 25mg/kg Administration: Short-term oral administration; for 24 hours Result: Activated TFEB and enhanced autophagy and lysosome biogenesis in rat brain.   Animal Model: Adult male Sprague-Dawley (SD) rats weighing 350 to 400g Dosage: 10mg/kg Administration: Chronic oral administration; daily; for 21 days Result: Activated TFEB and enhanced autophagy in rat brains.
保存条件：-20℃

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