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Kinetin riboside  ≥98%

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包装规格：100mg 500mg in glass bottle
溶解性：溶于DMSO（≥ 29 mg/mL）
产品描述：基本信息 产品编号：K10088 产品名称：Kinetin riboside CAS: 4338-47-0   储存条件 粉末 -20℃ 四年     分子式： C15H17N5O5 溶于液体 -80℃ 六个月 分子量 347.33 -20℃ 一个月 化学名：      Solubility (25°C)   体外 DMSO   Ethanol   Water   体内（现配现用）     ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 2.8791mL 14.3955mL 28.7911mL 5mM 0.5758mL 2.8791mL 5.7582mL 10mM 0.2879mL 1.4396mL 2.8791mL   生物活性 产品描述 一种细胞分裂素类似物，可诱导癌症细胞死亡。抑制HCT-15细胞增殖的IC50值为2.5μM。 靶点/IC50 2.5μM (HCT-15 cells)   体外研究 Kinetin riboside displays antiproliferative and apoptogenic activity against various human cancer cell lines. Kinetin riboside is able to inhibit the proliferation in HCT-15 human colon cancer cells in a dose -dependent manner (IC50=2.5μM). Kinetin riboside induces apoptosis in HeLa and mouse melanoma B16F-10 cells. Kinetin riboside disrupts the mitochondrial membrane potential and induces the release of cytochrome c and activation of caspase-3. Bad are up-regulated while Bcl-2 is down-regulated under kinetin riboside exposure. 体内研究 Kinetin riboside significantly suppresses tumor growth. The most effective anti-melanoma response is elicited at 40mg/kg.   推荐实验方法(仅供参考) 细胞实验:   HeLa and mouse melanoma B16F-10 cells are treated with 5,10,20μM kinetin riboside for 48h. 15μL of MTT solution (5mg/mL) is added to each well and cells are maintained for 4 h at 37℃. Hundred microlitres of solubilizing solution is then added. After an overnight incubation at room temperature, absorbance at 490nm is measured.   动物实验:   Mice: Male C57BL/6 mice are injected B16 F-10 cells. After 5 days for tumor growth, kinetin riboside (10, 20, 40mg/kg) is injected to tumor mass directly. Drug injection is performed once a 3 days for three times. After third injection of drug, mice are kept for 3 days with no injection and tumor mass is removed from each mouse and weighed.
保存条件：-20℃

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