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bpV(phen)  ≥95% V basis

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包装规格：5mg 25mg in glass bottle
溶解性：溶于水(20mg/mL in H2O)
产品描述：基本信息 产品编号： B10634 产品名称： bpV(phen) CAS: 42494-73-5   储存条件 粉末 -20℃ 四年     分子式： KVO5C12H8N2.XH2O 溶于液体     分子量 350.24     化学名：  Potassium bisperoxo(1,10-phenanthroline)oxovanadate (V) hydrate   生物活性 产品描述 一种胰岛素模拟物，是一种有效的蛋白酪氨酸磷酸酶(PTP)和PTEN抑制剂，对PTEN，PTP-β和PTP-1B的IC50为38nM，343nM和920nM。bpV(phen)在体外抑制原生动物寄生虫利什曼原虫的增殖 靶点 IC50: 38nM (PTEN), 343nM (PTP-β) and 920nM (PTP-1B) Parasite Leishmania Apoptosis 体外研究 bpV(phen) (5μM; 24.5 hours; H9c2 cells) treatment causes a further decrease of cell viability in H/R-injured H9c2 cells. bpV(phen) (5μM; 24.5 hours; H9c2 cells) treatment increases the apoptosis of H/R-injured H9c2 cells. bpV(phen) (5μM; 24.5 hours; H9c2 cells) treatment significantly promotes the accumulation of cytoplasmic Cytochrome C in H/R-injured H9c2 cells. After stimulation of bpV(phen), PTEN-induced putative kinase protein 1 (PINK1)/Parkin-mediated mitophagy is inhibited. bpV(phen) is an insulin-mimetic agent following insulin-receptor tyrosine kinase hyperphosphorylation and activation Cell Viability Assay Cell Line: Hypoxia/reoxygenation (H/R)-injured H9c2 cells Concentration: 5μM Incubation Time: 24.5 hours (hypoxia for 24 h; reoxygenation for 30 minutes) Result: Caused a further decrease of cell viability. Apoptosis Analysis Cell Line: Hypoxia/reoxygenation (H/R)-injured H9c2 cells Concentration: 5μM Incubation Time: 24.5 hours (hypoxia for 24 h; reoxygenation for 30 minutes) Result: Increased the apoptosis of H/R-injured H9c2 cells. Western Blot Analysis Cell Line: Hypoxia/reoxygenation (H/R)-injured H9c2 cells Concentration: 5μM Incubation Time: 24.5 hours (hypoxia for 24 h; reoxygenation for 30 minutes) Result: Showed an increased release of Cytochrome C. 体内研究 bpV(phen) (5mg/kg; intraperitoneal injection; daily; for 38 days; male BALB/c nude (nu/nu) athymic mice) treatment causes a significant reduction in average tumor volume Animal Model: Male BALB/c nude (nu/nu) athymic mice (6-7 weeks old) injected with PC-3 cells Dosage: 5mg/kg Administration: Intraperitoneal injection; daily; for 38 days Result: Caused a significant reduction in average tumor volume.
保存条件：-20℃

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