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HMN-154  ≥98% (HPLC)

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包装规格：1mg 5mg 25mg in glass bottle
溶解性：溶于DMSO（≥15mg/mL）
产品描述：一种新型的苯磺酰胺类抗癌化合物，与NF-YB相互作用，以此中断NF-Y异源三聚体与DNA的结合。HMN-154 interacts with NF-YB and thereby interrupts the binding of the NF-Y heterotrimer to DNA. NF-YB and thymosin β-10 are specific cellular binding proteins of HMN-154 and that this shared region is necessary for the binding to HMN-154. HMN-154 inhibits DNA binding of NF-Y to the human major histocompatibility complex class II human leukocyte antigen DRA Y-box sequence in a dose-dependent manner. HMN-154 shows very strong cytotoxicity against KB and colon38 cells with an IC50 value of 0.0026 and 0.003 μg/mL, respectively. HMN-154/BSA binds recombinant NF-YB or thymosin β-10 and the binding is inhibited by the addition of HMN-154 as the competitor. The binding between HMN-154 and NF-YB is specific and depends on its cytotoxicity.
保存条件：-20℃

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