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Remacemide hydrochloride  ≥98%

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包装规格：10mg in glass bottle
溶解性：溶 DMSO(＞10mg/mL)
产品描述：一种钠离子通道的中等强度抑制剂，是N-methyl-D-aspartate(NMDA)受体的弱无竞争力拮抗剂Remacemide, also known as PR-934423 and FPL 12924AA, is a low-affinity NMDA antagonist with sodium channel blocking properties. It has been studied for the treatment of acute ischemic stroke, epilepsy, Huntington's disease, and Parkinson's disease. Remacemide binds weakly and noncompetitively to the ionic channel site of the NMDA receptor complex. Remacemide binds both allosterically and in the channel. However, because remacemide binds so weakly to NMDAR, much of remacemide's in vivo effect against excitotoxicity is thought to be caused by its metabolic transformation to the more potent desglycine derivative FPL 12495.

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