QNZ46 ≥98%
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| 包装规格: | 5mg 10mg 50mg 100mg in glass bottle |
| 溶解性: | 溶于DMSO(≥4.5mg/ml) |
| 产品描述: | 一种NR2C/NR2D选择性的NMDA受体拮抗剂QNZ46 is a NMDA receptor antagonist. QNZ46 inhibits NMDA receptor function in a noncompetitive and voltage-independent manner by an unconventional mechanism that requires binding of glutamate to the GluN2 subunit, but not glycine binding to the GluN1 subunit. QNZ46 could provide an opportunity for the development of pharmacological tools and therapeutic agents that target NMDA receptors at a new site and modulate function by a novel mechanism. NMDA receptors are ionotropic glutamate receptors that mediate excitatory synaptic transmission and have been implicated in several neurological diseases. |
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