生物试剂
>
生化试剂
>
信号通路
> Anti-neurodegeneration agent 1
加入收藏 取消收藏

Anti-neurodegeneration agent 1  ≥95%

促销价¥{{model.attbuying.price}}

市场价¥0.00

累计销量0 累计评价0 人评论

别称 {{model.alias}}
中文名称 {{model.name}}
英文名称 {{model.enname}}
品牌 {{model.brand}}
CAS {{model.cas}}
分子式
分子量 {{model.molecularweight}}
MDL {{model.mdl}}
货号 {{model.procode}}
数量

+ -

件 库存{{model.attbuying.number}}件
立即购买 加入购物车 下载说明书

看了又看
包装规格：1g in glass bottle
产品描述：基本信息 产品编号： A12850 产品名称： Anti-neurodegeneration agent 1 CAS: 289893-23-8   储存条件 粉末 -20℃ 四年     分子式： C14H20ClN3O3 溶于液体     分子量 313.78     化学名：  N-(2-hydroxy-3-(1-piperidinyl)-propoxy)-pyridine-1-oxide-3-carboximidoyl chloride   生物活性 产品描述 一种用于神经退行性病变及其相关疾病研究的化合物。 体内研究 In Anti-neurodegeneration agent 1 (Compound I)-treated mSODl(G93A) mice, Western blot analysis reveals an observable 'band shift' of HSF-I, indicative of a stress-induced activation of HSF-I by hyper-phosphorylation. Immunostaining reveals that, at 120 days of age, expression of Hsp70 and Hsp90 is increased in the lumbar spinal cords of both untreated and Antineurodegeneration agent 1- treated SOD1(G93A) mice, although there is a clear increase in the intensity of Hsp70 and Hsp90 immunoreactivity in motor neurons of Anti-neurodegeneration agent 1-treated mSODl(G93A) mice. Anti-neurodegeneration agent I- treated mice live an average of 153 days (±2.6 SEM, n=7). This represents a significant increase in lifespan of over 22% (p=<0.001). The effect of beginning Anti-neurodegeneration agent 1 treatment at the time of disease onset is also tested by starting treatment at 70 days of age, when the first signs of locomotor defects are observed. Anti-neurodegeneration agent 1 treatment from 70 days of age extended the mean lifespan of mSODl(G93A) mice by 23 days, from 125 days (±1.8 SEM, n=18) in the untreated group to 148 days (±1.5 SEM, n=5) in the treated group. This represents an increase in lifespan of 18% (p=<0.001)   推荐实验方法(仅供参考) Animal Administration Mice Transgenic mice over-expressing human mutant SODl are used. Anti-neurodegeneration agent 1 is tested for the ability to prevent the progressive loss of motor neurons and muscle function known to occur in mSODl(G93A) mice. mSODl(G93A) mice of both sexes are treated daily with Anti-neurodegeneration agent 1 (10mg/kg, ip) from 35 or 70 days of age
保存条件：-20°C

猜你喜欢