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Norbinaltorphimine dihydrochloride  ≥98%

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包装规格：5mg 10mg 50mg in glass bottle
产品描述：基本信息 产品编号： N11387  产品名称： Norbinaltorphimine dihydrochloride CAS: 113158-34-2   储存条件 粉末 -20℃ 四年     分子式： C40H45Cl2N3O6 溶于液体 -80℃ 6个月 分子量： 734.71 -20℃ 1个月 化学名：  17,17'-(Dicyclopropylmethyl)-6,6',7,7'-6,6'-imino-7,7'-binorphinan-3,4',14,14'-tetrol dihydrochloride Solubility (25°C)：   体外:   DMSO   Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 1.3611mL 6.8054mL 13.6108mL 5mM 0.2722mL 1.3611mL 2.7222mL 10mM 0.1361mL 0.6805mL 1.3611mL   生物活性 产品描述 一种有效的和选择性的κ阿片受体 (κ opioid receptor) 拮抗剂。 靶点 κ opioid receptor   体外研究 Norbinaltorphimine reversibly antagonize the effects of κagonists with pA2 values of 10.2-10.4.Norbinaltorphimine is much less potent as an antagonist at μ and δ receptors,pA2 values are 7.4-7.6 and 7.6-7.8,respectively. 体内研究 Norbinaltorphimine has weak and inconsistent effects on THC-induced taste avoidance in adolescent rats in that Norbinaltorphimine both attenuates and strengthens taste avoidance dependent on dose and trial.Norbinaltorphimine has limited impact on the final one-bottle avoidance and no effects on the two-bottle preference test.Interestingly,Norbinaltorphimine has no effect on THC-induced taste avoidance in adult rats as well.Norbinaltorphimine pretreatment significantly attenuates stress-induced reinstatement of nicotine-CPP,but has no effect on nicotine-primed reinstatement.   推荐实验方法(仅供参考) 动物实验:   Rats Norbinaltorphimine is dissolved in sterile H2O at a concentration of 15mg/mL and administered subcutaneously (SC) at a dose of 15mg/kg.Male Sprague Dawley rats are ranked according to average water consumption on all habituation cycles and assigned to one of two groups [Norbinaltorphimine (n=42) and Vehicle (n=42)],such that mean water intake is comparable among groups.On PND 34 (approximately 24h prior to conditioning,see below),subjects assigned to the Norbinaltorphimine group are injected with Norbinaltorphimine (15mg/kg) and subjects assigned to the Vehicle group are injected with the Norbinaltorphimine vehicle at an equal volume.
保存条件：-20℃

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