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Dixyrazine  ≥99%

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包装规格：1mg 5mg 10mg 20mg in glass bottle
产品描述：基本信息 产品编号： D11542 产品名称： Dixyrazine CAS: 2470-73-7   储存条件 粉末 -20℃ 四年     分子式： C24H33N3O2S 溶于液体 -80℃ 六个月 分子量 427.60 -20℃ 一个月 化学名：  (2-Methyl-3-(1-hydroxyethoxyethyl-4-piperazinyl)propyl)-10-phenothiazine   生物活性 产品描述 Phenothiazine 衍生物，可预防注射硫酸鱼精蛋白引起的脑水肿。 体内研究 Pretreatment with Dixyrazine 10mg/kg completely prevents the brain oedema and significantly reduces the albumin increase in cerebrospinal fluid (CSF). The phenothiazine Dixyrazine (5mg/kg i.v.) has minimal, transient hypotensive effects but significantly reduces the leakage of 126I labelled serum albumin in conscious rats subjected to acute hypertension provoked by i.v. Adrenaline or Bicuculline. The diameters of pial arteries and veins are continuously measured with a multichannel videoangiometer through a closed cranial window in anesthetized rats before and after i.v. injection of Dixyrazine (5mg/kg). Dixyrazine, 5mg /kg, induces a slight transitory decrease in blood pressure (10-20 mm Hg). Maximum MAP is slightly but not significantly lower in Dixyrazine-treated rats   推荐实验方法(仅供参考) Animal Administration Rats Male Sprague-Dawley rats (200-225 g) are used. Evans blue and 125I-HSA are used as tracers, and controls are compared to rats pretreated with Dixyrazine 5mL/kg or 15mg/kg. The lower dose is given 15-20 min before the infusion of urea (that is the same interval as in the hypertension experiments). Because of larger effects on blood pressure with higher doses, the interval has to be extended to 40 min in this group. The radioactivity is determined in the right and left hemisphere and related to the activity in the blood.
保存条件：-20℃

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