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氧托溴铵  

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包装规格：5mg 10mg 25mg in glass bottle
产品描述：基本信息 产品编号： O10365 产品名称： Oxitropium Bromide CAS: 30286-75-0   储存条件 粉末 -20℃ 四年 分子式： C19H26BrNO4 溶于液体 -80℃ 二年 分子量： 412.32     化学名：  (1R,2R,4S,5S,7S)-9-ethyl-7-{[(2S)-3-hydroxy-2-phenylpropanoyl]oxy}-9-methyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane bromide Solubility (25°C)：   体外:   DMSO   Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   生物活性 产品描述 毒蕈碱受体拮抗剂。Oxitropium bromide 具有抗胆碱能支气管扩张作用，能用于哮喘和慢性阻塞性肺疾病的研究。 靶点 mAChR   体外研究 Oxitropium bromide is a muscarinic antagonist which blocks musucarinic acetylcholine receptors (mAChR).Incubation with oxitropium bromide of untreated diaphragm muscle and diaphragm muscle injected with endotoxin does not increase the force-frequency curves dose-dependently in vitro;however,it causes both types of muscle to be fatigue resistant. 体内研究 Oxitropium bromide inhalation shifts force-frequency curves upward at 2h after inhalation and inhibits the decrease of force-frequency curves due to endotoxin injection in vivo.Oxitropium bromide strongly and persistently inhibits the acetylcholine (ACh)-induced resistance.The increase in resistance induced by histamine, serotonin,leukotriene D4 or antigen is prevented by oxitropium bromide oxitropium bromide.Inhalation of the anticholinergic agent oxitropium bromide at doses of 1.5μg and higher greatly attenuates the decrease in mucus score produced by intravenous histamine but not by inhaled histamine.   推荐实验方法(仅供参考) 动物实验:   Mice:In the oxitropium bromide inhalation group,animals are given 2 puffs of inhalation from a oxitropium bromide MDI (metered dose inhaler) via a 75-mL spacer,and then diaphragm muscles are dissected and measured as to contractility immediately,1 hour,2 hours and 4 hours later (n=5 animals each).An animal is placed in a centrifugal tube (inner diameter=30mm) with a round hole (diameter=10mm) in the bottom,its nose and mouth being exposed through the hole to breath.An oxitropium bromide MDI (metered dose inhaler) releases 2 puffs into a spacer attached to the tube.Aerosols of oxitropium bromide are inhaled for about 10 seconds,while the animal is breathing spontaneously through the hole of the tube.
保存条件：-20℃

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