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LY341495  ≥98%

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包装规格：1mg 5mg 10mg 100mg in glass bottle
溶解性：溶于DMSO(6mg/mL超声）
产品描述：基本信息 产品编号： L11024 产品名称： LY341495 CAS: 201943-63-7   储存条件 粉末 -20℃ 四年     分子式： C20H19NO5 溶于液体 -80℃ 6个月 分子量： 353.37 -20℃ 1个月 化学名：  2-[(1s,2s)-2-Carboxycyclopropyl]-3-(9h-Xanthen-9-Yl)-D-Alanine Solubility (25°C)：   体外:   DMSO   Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 2.8299mL 14.1495mL 28.2990mL 5mM 0.5660mL 2.8299mL 5.6598mL 10mM 0.2830mL 1.4149mL 2.8299mL   生物活性 产品描述 一种代谢型谷氨酸受体 (mGluR) 拮抗剂。 靶点 mGluR 体内研究 LY341495 (0.3,1,and 3mg/kg,i.p.) displays a lower level of discrimination in rats.LY341495 (3.0mg/kg) decreases Dvl-2,pGSK-3α/β and β-catenin protein levels but Dvl-1,Dvl-3 and GSK-3α/β are unaffected in both the PFC and STR.LY341495 has the generally the opposite effect following acute and chronic administration compared to mGlu2/3 agonist,LY379268.LY341495 (3mg/kg,i.p.,2.5h) -induced c-Fos expression is not altered in either KO brain.LY341495 is almost inactive in the central extended amygdala [central nucleus of the amygdala,lateral (CeL) and bed nucleus of the stria terminalis,laterodorsal (BSTLD)] in mGluR3-KO mice.   推荐实验方法(仅供参考) 动物实验:   The rats are randomLy divided into six experimental groups (10 rats per group):vehicle and 0.05,0.1,0.3,1,and 3mg/kg LY341495.The LY341495 doses are selected on the basis of results from previous Published studies that evaluated the effects of this compound on cognition.The rats are subjected to a training session that consisted of two 2-min trials.The animals receive either vehicle or LY341495 immediately after T1.Using the 2-min trial duration,an ITI of 1h is used because recognition memory is still intact in untreated control rats under these experimental conditions.
保存条件：-20℃

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