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Biperiden  

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包装规格：5mg 10mg 25mg 50mg in glass bottle
产品简介：一种具有抗帕金森症活性的化合物，是中枢M1胆碱受体阻断剂 Biperiden is a muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine.
溶解性：DMSO ：50 mg/mL(160.53 mM;超声助溶) Water：1.82 mg/mL(5.84 mM;ultrasonic and warming and adjust pH to 5 with HCl and heat to 60°C)
储备液保存：-80°C, 6 months -20°C, 1 month
体外研究：Biperiden (29.6 μg/ml, 72 hours) can significantly induce apoptosis and inhibit proliferation at high doses in human pancreatic ductal adenocarcinoma cells.
体内研究：Biperiden (intraperitoneal injection, 10 mg/kg, everyday, 3 weeks) reduces tumor size by 83% in subcutaneous xenograft mouse using Panc-1 human pancreatic ductal adenocarcinoma cells. Biperiden (intraperitoneal injection, 8 mg/kg, every 8 hours, 10 days) can reduce frequency of spontaneous seizures and extracellular hippocampal glutamate levels while cause a long-term decrease in hippocampal excitability.
保存条件：-20℃
注意事项：1、为了您的安全和健康，请穿实验服并戴一次性手套操作。 2、以上信息仅做参考交流之用。

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