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Vinconate  

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包装规格：25mg 50mg 100mg in glass bottle
产品描述：基本信息 产品编号：V10213 产品名称：Vinconate CAS: 70704-03-9   储存条件 粉末 -20℃ 四年 分子式： C18H20N2O2 溶于液体 -80℃ 两年 分子量： 296.36     化学名：      Solubility (25°C)   体外 DMSO   Ethanol   Water   体内（现配现用）     ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 生物活性 产品描述 一种吲哚萘啶衍生物，可以刺激毒蕈碱乙酰胆碱受体 (muscariic acetylcholine receptor)。 靶点/IC50 muscariic acetylcholine receptor 体内研究 Treatment with Vinconate (50 to 200mg/kg p.o.) significantly increases dopamine concentrations in dialysate.Daily treatment with Vinconate (25mg/kg) for 7 days also significantly increases dopamine and serotonin concentrations in dialysate.Chronic treatment with Vinconate at a 10mg/kg significantly ameliorats the reduction in [3H]QNB binding in the nucleus accumbens and cerebellum.Furthermore,this Vinconate treatment significantly enhances [3H]QNB binding in the frontal cortex and hippocampus compare with the vehicle-treated aged animals.Also,chronic treatment with Vinconate at the higher dose significantly elevates [3H]QNB binding in the hippocampal CA3 sector and dentate gyrus compare with the vehicle-treated aged animals.Chronic treatment with Vinconate at a dose of 10mg/kg shows a significant reduction in [3H]HC binding only in the hippocampal CA1 sector compare with the vehicle-treated aged rats. 推荐实验方法(仅供参考) 动物实验:   344 male rats,6 months (adult) and 24 months (aged) of age, are allowed food and water ad lib throughout the experiments.Rats are divided into four groups;(1) 6-month-old;(2) vehicle (distilled water) is administered intraperitoneally (i.p.) once a day for 4 weeks before decapitation;(3) Vinconate at a dose of 10mg/kg is administered i.p.once a day for 4 weeks before decapitation;(4) Vinconate at a dose of 30mg/kg is administered i.p.once a day for 4 weeks before decapitation.Rats in groups (2) to (4) are 24 months old.Each group contains 6 to 7 rats.In addition,there are no significant differences among the three aged animal groups in body weight after drug or vehicle treatment.
保存条件：-20℃

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