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BMT-145027  ≥98%

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包装规格：1mg 5mg 10mg 25mg 50mg 100mg in glass bottle
产品简介：一种mGluR5 的正变构调节物且没有固有的激动剂活性，EC50值为47nM。
溶解性：溶于DMSO(2mg/mL超声 加热）
储备液保存：-80°C, 2 years -20°C, 1 year
靶点：mGluR5:47 nM (EC50)
体外研究：BMT-145027 is a compound with high MsLM stability (85% remaining), acceptable potency (EC50=47 nM), and a modest decrease in planarity (Fsp3 = 0.17). Importantly, BMT-145027 lacks inherent mGluR5 agonist activity when tested at concentrations up to 16 μM.
体内研究：Drug-treated and control mice are shown two identical objects. After a 24-h natural forgetting period, the mice are reintroduced to a familiar object while simultaneously presented with a novel object. Since mice spend more time exploring unfamiliar objects, improved memory is measured as time spent exploring the novel object. BMT-145027 leads to a significant increase in time spent with the novel object when dosed at 30 mg/kg, with an apparent trend in novel object preference at 10 mg/kg. Satellite animals indicates a total plasma concentration of 2800 nM at 30 mg/kg.
保存条件：-20℃
注意事项：1、为了您的安全和健康，请穿实验服并戴一次性手套操作。 2、以上信息仅做参考交流之用。

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