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4-P-PDOT  ≥98%

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包装规格：1mg 5mg 10mg 25mg 50mg 100mg in glass bottle
溶解性：溶于DMSO(40mg/mL超声）
产品描述：基本信息 产品编号： P70121 产品名称： 4-P-PDOT CAS: 134865-74-0   储存条件 粉末 -20℃ 四年 分子式： C19H21NO 溶于液体 -80℃ 6个月 分子量： 279.38 -20℃ 1个月 化学名：  N-(4-Phenyl-1,2,3,4-tetrahydronaphthalen-2-yl)propionamide Solubility (25°C)：   体外:   DMSO   Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 3.5794mL 17.8968mL 35.7935mL 5mM 0.7159mL 3.5794mL 7.1587mL 10mM 0.3579mL 1.7897mL 3.5794mL   生物活性 产品描述 一种有效的，选择性的和亲和性的褪黑激素受体 (MT2) 拮抗剂。 靶点 MT2 receptor   体外研究 In CHO-mt1 cells the amidotetraline 4-P-PDOT (10mM) has no effect on forskolin-stimulated cyclic AMP levels,either alone,or in the presence of Melatonin.In contrast,in CHO-MT2 cells,4-P-PDOT is an agonist, producing a concentration-dependent inhibition of forskolin stimulated cyclic AMP,with a pEC50 value of 8.72 and intrinsic activity of 0.86. Cell Viability Assay Cell Line: HT-29 and HeLa cells. Concentration: 30 min. Incubation Time: 50µM. Result: Produced a negligible effect on cell viability induced by melatonin. 体内研究 4-P-PDOT (0.5-1.0mg/kg;intravenous injection;klotho mutant mice) treatment significantly reverses antioxidant effects mediated by Melatonin.And significantly reverses the changes in the levels of these GSH-related parameters.4-P-PDOT treatment significantly reverses the memory function of Melatonin-treated klotho mutant mice.4-P-PDOT also counteracts Melatonin-mediated attenuation in response to the decreases in phospho-ERK expression,Nrf2 nuclear translocation,Nrf2 DNA-binding activity,and GCL mRNA expression in the hippocampi of klotho mutant mice. Animal Model: Klotho mutant mice treatment with Melatonin Dosage: 0.5mg/kg or 1.0mg/kg Administration: Intravenous injection Result: Significantly reversed antioxidant effects mediated by Melatonin.Significantly reversed the changes in the levels of these GSH-related parameters.Significantly reversed the memory function of Melatonin-treated klotho mutant mice.
保存条件：-20℃

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