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CG-806  ≥98%

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包装规格：25mg 50mg 100mg in glass bottle
溶解性：溶于DMSO（7.2mg/mL超声）
产品描述：一种口服，有效且非共价的泛-FLT3/泛-BTK 抑制剂，对 FLT3 的 IC50 值为 0.08 µM。CG-806 对 FLT3 野生型转染的 Ba/F3 细胞的 IC50 值为 11 nM。CG-806, also known as CG-026806, is a highly potent, non-covalent small molecule therapeutic agent, exhibiting a picomolar IC50 toward the FMS-like tyrosine kinase 3 with the Internal Tandem Duplication (FLT3-ITD and single-digit nanomolar IC50’s against Bruton’s tyrosine kinase (BTK) and its C481S mutant (BTK-C481S)). Further, CG-806 is a multi-targeted BTK / FLT3-ITD inhibitor as it impacts other relevant oncogenic targets, including the Aurora kinases (AURK), RET, MET, DDR2, and SRC kinases. CG-806 is currently being developed by Aptose Biosciences.
保存条件：-20℃

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