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ZD8321  

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包装规格：1mg in glass bottle
产品描述：基本信息 产品编号： Z10090 产品名称： ZD8321 CAS: 182073-77-4   储存条件 粉末 -20℃ 四年     分子式： C18H28F3N3O5 溶于液体 -80℃ 六个月 分子量 423.43 -20℃ 一个月 化学名：  N-(Methoxycarbonyl)-L-valyl-N-((1S)-3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl)-L-prolinamide   生物活性 产品描述 一种人 Neutrophil elastase (NE) 的有效抑制剂。 靶点 Ki: 13±1.7nM (Neutrophil elastase) 体外研究 TNFα-activated HUVEC is dose dependently inhibited by ZD8321.The adhesion between cancer cells with high elastase activity and TNFα-activated HUVEC is also inhibited by ZD8321. Expression of cell surface E-selectin by NE stimulation is suppressed in the presence of ZD8321. The concentration of soluble E-selectin in the medium increases after adhesive reaction between neutrophils and HUVEC. This increase is also dose dependently inhibited by ZD8321   推荐实验方法(仅供参考) Cell Assay HUVECs are cultured in RPMI 1640 containing 5% FBS for 6h in collagen-coated, 24-well plates before the experiment. Some of the confluent HUVECs are further incubated with TNFα (1ng/mL) and ZD8321 (0-50mM), or with human NE (0-100ng/mL) for 4h at 37°C. For adhesion assays, cancer cells resuspended in RPMI 1640 containing 5% FBS are added to each HUVEClayered well. The plates are shaken at 700 rpm for 10 min at room temperature, washed twice with PBS, and examined by phase-contrast microscopy to determine the number of cells bound onto the HUVEC monolayer. The adhesive reactions of neutrophils to HUVEC are also analyzed in this manner
保存条件：-20℃

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