生物试剂
>
生化试剂
>
信号通路
> 茚地那韦
加入收藏 取消收藏

茚地那韦  98%

促销价¥{{model.attbuying.price}}

市场价¥0.00

累计销量0 累计评价0 人评论

别称 {{model.alias}}
中文名称 {{model.name}}
英文名称 {{model.enname}}
品牌 {{model.brand}}
CAS {{model.cas}}
分子式
分子量 {{model.molecularweight}}
MDL {{model.mdl}}
货号 {{model.procode}}
数量

+ -

件 库存{{model.attbuying.number}}件
立即购买 加入购物车 下载说明书

看了又看
包装规格：10mg in glass bottle
产品简介：一种HIV蛋白酶抑制剂，具有很好的口服生物相容性。 Indinavir (IDV) is a protease inhibitor used as a component of highly active antiretroviral therapy to treat HIV/AIDS.
溶解性：溶于水(＞15m/mL)
储备液保存：-80°C, 6 months; -20°C, 1 month。
靶点：HIV-1;MMP-2
体外研究：Indinavir (0-50 μM; 18 h) blocks lymphocyte cell cycle in G0/G1 phase in PBMCs cells and impairs lymphoproliferative responses. Indinavir (40 μM-40 nM; 5 days) inhibits cell invasion and (40 μM-40 nM; 48 h) MMPs-2 activation of the Huh7 and SK-HEP-1 hepatocarcinoma cells in vitro.
体内研究：Indinavir (70 mg/kg; i.g.; once a day for 3 weeks) inhibits the growth of hepatocarcinoma cells in vivo.
细胞实验：Cell Viability Assay Cell Line：PBMCs (from healthy and HIV-infected volunteers) Concentration：0-50 µM Incubation Time：18 h (pretreatment; stimulation with anti-CD3 for an additional 48 hours) Result：Blocked anti-CD3-induced cell-cycle progression in a dose-dependent manner. Resulted in dose-dependent reduction of lymphoproliferative responses. Cell Invasion Assay Cell Line：Huh7 and SK-HEP-1 cells Concentration：40 µM-40 nM Incubation Time：5 days Result：Reduced ability to invade an in vitro constituted extracellular matrix for both cell lines treated compared with the untreated cells. Western Blot Analysis Cell Line：Huh7 and SK-HEP-1 cells Concentration：40 µM-40 nM Incubation Time：48 h Result：Blocked the conversion of latent MMP-2 to its 62/64-kDa active form.
动物实验：Animal Model：Nude mice(s.c. into Huh7 and SK-HEP-1 cells). Dosage：70 mg/kg Administration：Oral gavage; once a day for 3 weeks. Result：Delaied the growth of s.c. implanted hepatocarcinoma xenografts in nude mice compared with placebo.
保存条件：-20℃
注意事项：1、为了您的安全和健康，请穿实验服并戴一次性手套操作。 2、以上信息仅做参考交流之用。

猜你喜欢