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Cirsiliol  

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包装规格：1mg in glass bottle
产品描述：基本信息 产品编号： C70137 产品名称： Cirsiliol CAS: 34334-69-5   储存条件 粉末 -20℃ 四年     分子式： C17H14O7 溶于液体     分子量 330.29     化学名：  2-(3,4-dihydroxyphenyl)-5-hydroxy-6,7-dimethoxychromen-4-one   生物活性 产品描述 有效和选择性的5-脂氧合酶(5-lipoxygenase)抑制剂，并且是竞争性低亲和力的苯二氮卓受体配体。 靶点 5-Lipoxygenase 体外研究 In concentrations from 0.01 to 300μM, cirsiliol causes concentration-dependent relaxation of rat isolated ileum. Cirsiliol may inhibit Ca2+ influx but stimulates Ca2+ release from intracellular stores[1]. Treatment with rhamnetin or cirsiliol reduces the proliferation of NSCLC cells through the suppression of radiation-induced Notch-1 expression 体内研究 In xenograft mouse model, tumor volume is significantly reduced by combinational treatment with irradiation and rhamnetin or cirsiliol compared with irradiation alone   推荐实验方法(仅供参考) Cell Assay NSCLC, NCI-H1299, NCI-H460, WI-26 VA4 and MRC-5 cell lines are exposed to a single dose of γ-rays. Cells are then treated with rhamnetin and cirsiliol (5, 10, 15, 20, 25μM) dissolved in DMSO for 4h     Animal Administration Mice BALB/c athymic nude mice are injected with 2×106 NCI-H1299 cells. When the tumor has acquired a minimal volume of 200mm3 , DMSO or Cirsiliol (200μg/kg body weight) is administered intraperitoneally every day for 25 days. The animals are also irradiated with 10 Gy once a week for 3 weeks. On day 25, the tumors are excised and subjected to further analyses
保存条件：-20℃

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